It worked wonderfully for me for about ten years, and then abruptly stopped working; when my doctor suggested I try Cymbalta (DO NOT DO THIS, CYMBALTA IS HORRIBLE) it really didn't take me that long to wean off. About three weeks from full dosage to nothing, and there wasn't any nausea or sleep disturbance; I did feel more jittery and anxious, but I think that's due to the underlying condition rather than to side effects from Zoloft withdrawal.