When I went off the stuff, I was moving onto another antidepressant. That means that at first, I was taking Zoloft with a small dose of the other stuff, then tapering off the Zoloft and slowly increasing the other antidepressant. Sadly, neither Zoloft nor the other antidepressant really worked properly. It took some months before my doc and I hit on the right medication, which was another class of drug altogether.